Peptide and Dendritic Cell Vaccines
نویسندگان
چکیده
منابع مشابه
Peptide and dendritic cell vaccines.
There has been a rush to convert discovery of new melanoma antigens into cancer vaccines for the therapy of melanoma. The result has been disappointing from a clinical standpoint. The premise behind rapid pursuit of peptide vaccines for melanoma therapy was that the spontaneous tumor-associated immune response was too weak to be effective. However, it is increasingly clear that the host-tumor r...
متن کاملJ‐LEAPS peptide and LEAPS dendritic cell vaccines
The J-LEAPS vaccines contain a peptide from β-2-microglobulin covalently attached to disease-related peptides of 8-30 amino acids which contain a T cell epitope. The J-LEAPS vaccines can initiate a protective Th1 immune response or modulate an ongoing Th17 autoimmune response to the peptide. J-LEAPS vaccines activate and direct the nature of the subsequent immune response by promoting the matur...
متن کاملDendritic cell-based vaccines
Dendritic cell (DC)-based anticancer vaccines have yielded disappointing results in a multitude of clinical trials. New data suggest that the clinical efficacy of DC-based vaccines may be dependent on the paracrine production of interleukin-12 in the course of antigen presentation and the consequent development of therapeutic Type 1 CD8+ T-cell immunity.
متن کاملDendritic cell vaccines Paul
1. Abstract 2. Introduction 3. Preparation of dendritic cells 3.1. Sources of dendritic cells 3.2. Dendritic cell mobilization strategies 3.3. Dendritic cell culture conditions 3.4. Methods of loading dendritic cells with tumor antigens 3.5. Dendritic cell maturation 3.6. The role of helper antigens 3.7. cryopreservation of dendritic cells 4. Administration of dendritic cell vaccines 4.1. Route...
متن کاملDendritic Cell-Targeted Vaccines
Despite significant effort, the development of effective vaccines inducing strong and durable T-cell responses against intracellular pathogens and cancer cells has remained a challenge. The initiation of effector CD8(+) T-cell responses requires the presentation of peptides derived from internalized antigen on class I major histocompatibility complex molecules by dendritic cells (DCs) in a proc...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2006
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-05-2541